Preparation and in vitro Characterization of Porous Carrier–Based Glipizide Floating Microspheres for Gastric Delivery
2011
Floating Microspheres for Glipizide Delivery
publication
Evidence: moderate
Author Information
Author(s): Pandya N, Pandya M, Bhaskar V
Primary Institution: M.P. Patel College of Pharmacy
Hypothesis
Can floating microspheres improve the gastric delivery of glipizide?
Conclusion
The study successfully developed floating microspheres that enhance the gastric delivery and release of glipizide.
Supporting Evidence
- The microspheres showed prolonged drug release for about 8 hours.
- Formulation CS4 had the best floating ability with 88% buoyancy in simulated gastric fluid.
- The release pattern followed the Higuchi matrix model and the Peppas-Korsmeyer model.
Takeaway
Scientists made tiny balls that float in your stomach to help a diabetes medicine work better and last longer.
Methodology
Floating microspheres were prepared using the emulsion solvent diffusion technique with calcium silicate as a carrier and glipizide as the drug.
Limitations
The study did not explore long-term stability beyond 6 months or the effects in vivo.
Digital Object Identifier (DOI)
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