Cyclins A and D1 and p21 in Renal Cell Cancer
Author Information
Author(s): Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Syrjänen K, Kosma V-M
Primary Institution: Kuopio University Hospital
Hypothesis
The study investigates the expression of cyclins A and D1 and p21(waf1/cip1) in renal cell carcinomas and their relationship to clinical outcomes.
Conclusion
Cyclin A is a powerful and independent prognostic factor in renal cell carcinoma, while cyclin D1 and p21(waf1/cip1) do not have prognostic value.
Supporting Evidence
- Cyclin A was related to venous invasion and high nuclear grade.
- Cyclin D1 was linked with age over 65 years and low nuclear grade.
- An inverse correlation was present between p21(waf1/cip1) and cyclin D1.
- Cyclin A predicted survival in the entire study group and various subgroups.
- Cyclin D1 and p21(waf1/cip1) were not significantly related to survival.
Takeaway
This study looked at how certain proteins in kidney cancer cells can help predict how well patients will do. It found that one protein, cyclin A, is really good at predicting patient outcomes.
Methodology
The study analyzed the expressions of cyclins A, D1, and p21(waf1/cip1) in 118 renal cell carcinomas and their relationship to clinical and histopathological parameters.
Statistical Information
P-Value
P ≤ 0.006 for cyclin A, P ≤ 0.05 for cyclin D1, P = 0.011 for p21
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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