High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
1999
Benzoporphyrin derivative in melanoma treatment
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Busetti A, Soncin M, Jori G, Rodgers M A J
Primary Institution: Department of Biology, University of Padova, Padova, Italy
Hypothesis
Benzoporphyrin derivative monoacid ring A (verteporfin) can effectively treat pigmented malignant melanoma through photodynamic therapy.
Conclusion
The study found that benzoporphyrin derivative significantly delayed tumor growth and induced necrosis in melanoma.
Supporting Evidence
- Benzoporphyrin derivative showed maximal accumulation in tumors within 1-3 hours after injection.
- Irradiation at 3 hours post-injection induced tumor necrosis.
- Irradiation at 9 hours post-injection delayed tumor growth by 14 days.
Takeaway
This study shows that a special drug can help treat skin cancer by using light to make the cancer cells go away.
Methodology
C57/BL6 mice with transplanted B1 melanoma were treated with benzoporphyrin derivative and irradiated with specific light wavelengths.
Participant Demographics
C57/BL6 mice
Digital Object Identifier (DOI)
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