Breast Cancer and Chromosomal Radiosensitivity
Author Information
Author(s): Riches A C, Bryant P E, Steel C M, Gleig A, Robertson A J, Preece P E, Thompson A M
Primary Institution: Medical Science and Human Biology, School of Biology, University of St Andrews
Hypothesis
Does chromosomal radiosensitivity in G2-phase lymphocytes identify breast cancer patients with distinctive tumor characteristics?
Conclusion
High chromosomal radiosensitivity in breast cancer patients is associated with distinctive tumor characteristics and a better prognosis.
Supporting Evidence
- 46% of breast cancer patients showed high radiosensitivity compared to 14% of controls.
- Predicted survival at 15 years was 55% for high G2RS patients versus 36% for low G2RS patients.
- 81% of tumors from high G2RS patients were estrogen receptor positive compared to 45% from low G2RS patients.
Takeaway
Some women with breast cancer are more sensitive to radiation, which can help doctors understand their cancer better and predict how well they might do.
Methodology
Chromatid break frequencies were compared between untreated breast cancer patients and hospital outpatient controls.
Participant Demographics
Breast cancer patients and hospital outpatient controls.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website