XRCC1 Gene Variants and Nasopharyngeal Carcinoma Risk
Author Information
Author(s): Cao Yun, Miao Xiao-Ping, Huang Ma-Yan, Deng Ling, Hu Li-Fu, Ernberg Ingemar, Zeng Yi-Xin, Lin Dong-Xin, Shao Jian-Yong
Primary Institution: Sun Yat-Sen University Cancer Center
Hypothesis
Two common single nucleotide polymorphisms of XRCC1 are related to the risk of nasopharyngeal carcinoma and interact with tobacco smoking.
Conclusion
The XRCC1 Trp194Trp variant genotype is associated with a reduced risk of developing nasopharyngeal carcinoma in the Cantonese population, especially among males and smokers.
Supporting Evidence
- Individuals with the Trp194Trp genotype had a nearly 0.50-fold decreased risk of developing NPC compared to those with the Arg194Arg genotype.
- Males carrying the XRCC1 194Trp/Trp genotype had a reduced risk of developing NPC (OR = 0.32).
- Smokers with the XRCC1 194Trp/Trp genotype had an OR of 0.34, significantly lower than nonsmokers.
Takeaway
Some people have a gene that helps protect them from a type of throat cancer, especially if they smoke. This study looked at how that gene works in people from southern China.
Methodology
A hospital-based case-control study using polymerase chain reaction-restriction fragment length polymorphism analysis.
Limitations
The study had a limited selection of cases and needs confirmation in larger studies.
Participant Demographics
462 NPC patients and 511 healthy controls, all ethnic Cantonese living in southern China.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI, 0.27–0.86
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website