p53 Protein and Survival in Gastric Cancer
Author Information
Author(s): B.V. Joypaull, D. Hopwood, E.L. Newman, S. Qureshi, A. Grant, S.A. Ogston, D.P. Lane, A. Cuschieri
Primary Institution: University of Dundee, Ninewells Hospital and Medical School
Hypothesis
Is there a correlation between p53 expression and survival in gastric adenocarcinoma patients?
Conclusion
Overexpression of the p53 protein is associated with significantly shortened survival in gastric cancer patients.
Supporting Evidence
- 46% of gastric carcinomas expressed high levels of p53.
- Patients with p53-positive tumours had a 5-year survival rate of 3%, compared to 16% for those with p53-negative tumours.
- The odds ratio of death for p53-positive patients was 1.89.
- Life table analysis showed a significant association between p53 expression and survival.
Takeaway
This study found that many people with a certain type of stomach cancer have a protein called p53 that can make them live shorter lives.
Methodology
Immunohistochemical analysis of p53 expression in formalin-fixed, paraffin-embedded tissues from 206 gastric adenocarcinoma patients.
Limitations
The study did not include patients who received adjuvant therapy, which may limit the generalizability of the findings.
Participant Demographics
93 males and 113 females, mean age 67 years, ranging from 38 to 83 years.
Statistical Information
P-Value
0.0062
Confidence Interval
1.33-2.69
Statistical Significance
p<0.01
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