The use of silicon-based tethers for the Pauson-Khand reaction
2007
Using Silicon Tethers in the Pauson-Khand Reaction
publication
Evidence: low
Author Information
Author(s): Dobbs Adrian P, Miller Ian J, Martinović Saša
Primary Institution: Queen Mary University of London
Hypothesis
Can silicon-based tethers improve the Pauson-Khand reaction?
Conclusion
Silicon tethers have shown limited success in the Pauson-Khand reaction, with only diisopropylsilyl ethers demonstrating potential.
Supporting Evidence
- Silicon tethers were not compatible with the Pauson-Khand reaction in most cases.
- Only diisopropylsilyl ethers showed any successful cyclisation.
- Attempts to use silyl acetals and other silicon tethers were largely unsuccessful.
Takeaway
The study looked at using silicon to help a chemical reaction work better, but it mostly didn't work as hoped.
Methodology
Investigated various silicon-based tethers and promoters for the Pauson-Khand reaction.
Limitations
Only diisopropylsilyl ethers showed potential; other silicon tethers were ineffective.
Digital Object Identifier (DOI)
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