Cyclin D1 and Aggressive DNA Patterns in Oral Cancer
Author Information
Author(s): Das Satya N. Khare, Pratima Singh, Manoj K Sharma, Suresh C.
Primary Institution: All India Institute of Medical Sciences, New Delhi, India
Hypothesis
The study investigates the correlation between cyclin D1 overexpression and clinicopathological features in patients with tobacco-related oral squamous cell carcinoma.
Conclusion
Higher expression of cyclin D1 in oral cancer is linked to cell proliferation, differentiation, and lymph node invasion.
Supporting Evidence
- Cyclin D1 was overexpressed in 66.6% of the cases studied.
- Higher cyclin D1 expression correlated with advanced age and higher tumor stage.
- Patients with aneuploid tumors showed a higher frequency of cyclin D1 immunoreactivity.
Takeaway
This study found that a protein called cyclin D1 is more common in aggressive oral cancers, which can help doctors decide on the best treatment.
Methodology
Immunohistochemistry for cyclin D1 and DNA flowcytometry for cell cycle parameters were performed on tumor samples from 45 patients.
Participant Demographics
The study included 45 patients, with a mean age of 53.2 years; 80% were males and 20% were females.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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