MiCK: A Database of Gut Microbial Genes Linked with Chemoresistance in Cancer Patients
Author Information
Author(s): Shahzaib Muhammad, Muaz Muhammad, Zubair Muhammad Hasnain, Kayani Masood Ur Rehman
Primary Institution: National University of Sciences and Technology (NUST), Islamabad, Pakistan
Hypothesis
The human gut microbiome influences chemoresistance in cancer patients through microbial gene sequences.
Conclusion
The MiCK database catalogs 1.6 million microbial gene sequences associated with chemoresistance, providing a valuable resource for researchers.
Supporting Evidence
- MiCK contains 1.6 million sequences of 29 gene types linked to chemoresistance and drug metabolism.
- The database provides a user-friendly web interface for sequence search and download functionalities.
- MiCK aims to facilitate the understanding and mitigation of chemoresistance in cancers.
Takeaway
Scientists created a database that helps understand how gut bacteria can affect cancer treatment. It has a lot of information about genes that might make cancer drugs less effective.
Methodology
The database was created by manually curating microbial gene sequences from literature and existing databases, focusing on their association with chemoresistance.
Limitations
The database may not cover all microbial genes involved in chemoresistance due to the limitations of current literature.
Digital Object Identifier (DOI)
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