Synthesis of Diverse Natural-Product-Like Molecules
Author Information
Author(s): Morton Daniel Leach, Stuart Cordier, Christopher Warriner, Stuart Nelson
Primary Institution: University of Leeds
Hypothesis
Can we create a library of small molecules with high scaffold diversity using a combinatorial approach?
Conclusion
The study successfully developed a method to synthesize over eighty distinct molecular scaffolds, demonstrating high structural diversity.
Supporting Evidence
- The study created a library of 96 products with distinct molecular scaffolds.
- High-throughput screens of the synthesized libraries provided useful tools for chemical genetic studies.
- Approximately 65% of the deprotected scaffolds were novel and not previously prepared.
Takeaway
The researchers figured out how to make a lot of different tiny molecules that look like natural products using a clever method.
Methodology
The study used a combinatorial approach involving the attachment of unsaturated building blocks to a fluorous-tagged linker and employed metathesis reactions to create diverse scaffolds.
Limitations
Some reactions did not proceed to completion, and yields varied widely.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website