Efficacy and Tolerability of Fitostimoline in Two Different Forms (Soaked Gauzes and Cream) and Citrizan Gel in the Topical Treatment of Second-Degree Superficial Cutaneous Burns
2011

Effectiveness of Fitostimoline for Treating Burns

Sample size: 227 publication Evidence: moderate

Author Information

Author(s): Patrizia Martini, Carlo Mazzatenta, Giorgio Saponati

Primary Institution: U.O. di Dermatologia, Campo di Marte Hospital, Azienda USL 2, Lucca, Italy

Hypothesis

Is Fitostimoline more effective than catalase gel in treating second-degree superficial cutaneous burns?

Conclusion

Fitostimoline treatments resulted in higher healing rates compared to catalase gel for second-degree burns.

Supporting Evidence

  • Fitostimoline gauzes had a healing rate of 97.3%.
  • Fitostimoline cream had a healing rate of 91.5%.
  • Catalase gel had a healing rate of 84.5%.
  • Patients treated with Fitostimoline reported less pain at medication and rest.
  • The median time to healing was 11 days for Fitostimoline gauzes.

Takeaway

This study tested two types of Fitostimoline for treating burns and found they worked better than a gel treatment.

Methodology

Patients were randomly assigned to receive either Fitostimoline soaked gauzes, Fitostimoline cream, or catalase gel for up to 20 days.

Potential Biases

The open-label design may introduce bias in subjective assessments.

Limitations

The study had a higher dropout rate in the catalase gel group, which may have affected the results.

Participant Demographics

Mean age 41.3 years, 52% females.

Statistical Information

P-Value

0.020

Confidence Interval

0.15–0.84

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1155/2011/978291

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