Death Risk in Pediatric Cancer Patients with Sepsis Undergoing CRRT
Author Information
Author(s): Ma Xiaoxuan, Dou Jiaying, Wang Chunxia, Miao Huijie, Shi Jingyi, Cui Yun, Zhou Yiping, Zhang Yucai
Primary Institution: Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Hypothesis
What are the outcomes and risk factors for pediatric patients with cancer-related sepsis requiring continuous renal replacement therapy?
Conclusion
The study found that pediatric patients with cancer-related sepsis requiring CRRT have a high mortality rate, with specific risk factors identified.
Supporting Evidence
- The overall PICU mortality was 28.1%, with 41.3% in cancer-related sepsis patients compared to 22.0% in non-cancer patients.
- Higher p-SOFA scores and lower albumin levels were identified as independent risk factors for mortality.
- Patients with cancer-related sepsis had significantly higher mortality rates than those with non-cancer-related sepsis.
Takeaway
Kids with cancer who get really sick from infections and need special kidney treatment have a high chance of not making it, especially if their health is already weak.
Methodology
This was a retrospective cohort study analyzing pediatric patients with cancer-related sepsis who required CRRT from January 2017 to December 2021.
Potential Biases
Potential bias due to the retrospective nature of the study and exclusion criteria that may affect the sample.
Limitations
The study was conducted in a single PICU, limiting generalizability, and had a small sample size without matched baseline characteristics.
Participant Demographics
Patients aged from 28 days to 18 years, predominantly male (55.5%).
Statistical Information
P-Value
0.016
Confidence Interval
95% CI: 0.730–0.974
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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