Salmonella Typhimurium Uses Inflammation to Compete with Gut Bacteria
Author Information
Author(s): Stecher Bärbel, Robbiani Riccardo, Walker Alan W, Westendorf Astrid M, Barthel Manja, Kremer Marcus, Chaffron Samuel, Macpherson Andrew J, Buer Jan, Parkhill Julian, Dougan Gordon, von Mering Christian, Hardt Wolf-Dietrich
Primary Institution: Institute of Microbiology, Swiss Institute of Technology Zurich
Hypothesis
How does Salmonella Typhimurium manipulate the intestinal microbiota to overcome colonization resistance?
Conclusion
Inflammation is necessary for Salmonella Typhimurium to outcompete the protective gut microbiota.
Supporting Evidence
- Inflammation induced by Salmonella Typhimurium changes the composition of the gut microbiota.
- An avirulent mutant of Salmonella was outcompeted by the microbiota.
- Inflammation can be induced by co-infection with wild-type Salmonella.
Takeaway
Salmonella can use inflammation in the gut to push out good bacteria and take over the space for itself.
Methodology
The study used a mouse model of colitis to analyze the interaction between Salmonella Typhimurium and the gut microbiota.
Participant Demographics
Mice used in the study included various strains, including C57BL/6 and IL10−/−.
Statistical Information
P-Value
p ≤ 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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