Increased Risk of Biliary Tract Cancer After Gastric Surgery
Author Information
Author(s): C. Caygill, M. Hill, J. Kirkham, T.C. Northfield
Primary Institution: St James Hospital
Hypothesis
Does gastric surgery increase the risk of biliary tract cancer over time?
Conclusion
The study found a significant increase in the risk of biliary tract cancer, particularly gallbladder cancer, after a latency of 20 years following gastric surgery.
Supporting Evidence
- Patients who had gastric surgery showed no increased risk of biliary tract cancer within the first 20 years.
- After 20 years, the risk of biliary tract cancer increased significantly, especially for gastric ulcer patients.
- The excess risk for gallbladder cancer was found to be 14.7 fold after 20 years.
Takeaway
If someone has surgery for stomach ulcers, they might have a higher chance of getting a rare type of cancer in their bile ducts or gallbladder many years later.
Methodology
Analysis of mortality and cancer risk in 4,466 peptic ulcer patients who underwent gastric surgery at least 25 years prior.
Limitations
The study is limited by the rarity of biliary tract cancer, making it difficult to gather extensive data.
Participant Demographics
Patients treated surgically for peptic ulcer at St James Hospital, predominantly male.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Want to read the original?
Access the complete publication on the publisher's website