Effects of Methylphenidate on ADHD in Children
Author Information
Author(s): Lee James, Grizenko Natalie, Bhat Venkataramana, Sengupta Sarojini, Polotskaia Anna, Joober Ridha
Primary Institution: McGill University
Hypothesis
The study aimed to explore the correlation between therapeutic response and side effects of methylphenidate in children with ADHD.
Conclusion
The study suggests that mood/anxiety side effects may influence parents' perceptions of their children's improvement while on methylphenidate.
Supporting Evidence
- The side effects of insomnia and decreased appetite were significantly more frequent with methylphenidate compared to placebo.
- Significant negative correlations were found between mood/anxiety side effects and parents' evaluations of therapeutic response.
- Most evaluations were conducted by mothers, with a small number by fathers or both parents.
Takeaway
This study looked at how a medicine for ADHD affects kids and how parents see those effects. It found that some side effects can make parents think their kids aren't getting better.
Methodology
A double-blind, crossover trial where children were given both placebo and methylphenidate for one week each, with assessments from parents and teachers.
Potential Biases
Parental evaluations may be influenced by their own expectations and anxiety regarding treatment.
Limitations
The study's dosage and duration may not reflect common clinical practice, and it relied solely on parent reports for side effects.
Participant Demographics
Children aged 6-12 years with ADHD, primarily evaluated by mothers.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website