Effects of Cistus monspeliensis Leaf Extract on Cell Health
Author Information
Author(s): Al-Naqeb Ghanya, Zorzi Gianluca, Oldani Amanda, Azzalin Alberto, Avesani Linda, Guzzo Flavia, Pascale Alessia, De Giuseppe Rachele, Cena Hellas
Primary Institution: University of Pavia
Hypothesis
Does Cistus monspeliensis leaf extract have genotoxic and antigenotoxic effects?
Conclusion
Cistus monspeliensis extract is not genotoxic and shows a protective effect against genotoxic agents at low concentrations.
Supporting Evidence
- Cistus monspeliensis extract did not induce significant micronuclei frequency.
- At low concentrations, the extract showed a significant protective effect against MMC-induced micronuclei frequency.
- The study utilized advanced image analysis systems for the automated in vitro CBMN assay.
Takeaway
This study looked at a plant extract to see if it could harm cells or help protect them from damage. It found that the extract is safe and can help protect cells when used in small amounts.
Methodology
The study used an in vitro cytokinesis-block micronucleus assay in CHO-K1 cells to evaluate the effects of the extract.
Limitations
The study was conducted in vitro, and further in vivo studies are needed to confirm the findings.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website