METTL13 and its Role in Bladder Cancer
Author Information
Author(s): Zhang Jun, He Jiejie, Qiang Ziyang, Zhang Junli, Hao Fengchen, Song Shiqi, Chen Xiuying, Ma Wei
Primary Institution: Affiliated Hospital of Qinghai University
Hypothesis
METTL13 might promote BC development through the activation of the PI3K/AKT signaling pathway.
Conclusion
This study demonstrated that METTL13 promoted the malignant behaviors of BC cells through activation of the PI3K/AKT signaling pathway.
Supporting Evidence
- METTL13 was upregulated in bladder cancer cells.
- Silencing METTL13 decreased cell viability, migration, and invasion in bladder cancer cells.
- METTL13 knockdown inhibited tumor growth in vivo.
Takeaway
METTL13 helps bladder cancer cells grow and spread by turning on a specific signaling pathway, and blocking this pathway can stop these effects.
Methodology
In vitro experiments were conducted using J82 and T24 bladder cancer cell lines, assessing cell viability, migration, and invasion, along with in vivo experiments in nude mice.
Limitations
Insufficient clinical samples were obtained for comprehensive studies.
Participant Demographics
Female BALB/c nude mice were used for in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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