Dieldrin Increases Tumors in Mice
Author Information
Author(s): Cameron Heather L., Foster Warren G.
Primary Institution: McMaster University
Hypothesis
Dieldrin modulates breast cancer pathogenesis by altering expression of novel growth factors thought to be involved in cancer progression.
Conclusion
Developmental exposure to dieldrin causes increased tumor burden in genetically predisposed mice.
Supporting Evidence
- Dieldrin treatment significantly increased the total tumor burden in mice.
- The highest dose of dieldrin led to increased expression of BDNF and TrkB in tumors.
- Pregnancy rates were significantly reduced in the highest dieldrin treatment group.
Takeaway
This study found that a pesticide called dieldrin can make mice more likely to develop breast tumors, especially when they are exposed to it before birth and while nursing.
Methodology
Female mice were treated with dieldrin or vehicle during pregnancy and lactation, and tumor development was assessed at 22 weeks.
Limitations
The study primarily used a mouse model, which may not fully replicate human breast cancer development.
Participant Demographics
FVB/N-TgMMTV-neu transgenic mice.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 1.17–3.57
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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