Recombination Rates and Evolution in Listeria monocytogenes
Author Information
Author(s): Henk C den Bakker, Xavier Didelot, Esther D Fortes, Kendra K Nightingale, Martin Wiedmann
Primary Institution: Cornell University
Hypothesis
What is the role of recombination in the evolution of Listeria monocytogenes lineages I and II?
Conclusion
Both lineages of Listeria monocytogenes have experienced a population bottleneck, but lineage II shows a significantly higher rate of recombination than lineage I.
Supporting Evidence
- Recombination is more prevalent in lineage II than in lineage I.
- Lineage II has a higher genetic variability due to more frequent recombination.
- Both lineages have suffered a population bottleneck.
Takeaway
This study found that two types of Listeria bacteria can change and mix their genes differently, which helps them survive and evolve.
Methodology
The study used multilocus sequence typing data for 195 L. monocytogenes isolates and analyzed recombination rates using STRUCTURE and ClonalFrame.
Potential Biases
Potential bias due to the selection of isolates from various sources, which may not represent the entire population.
Limitations
The study's conclusions may be limited by the small number of lineage III isolates and the focus on specific genes.
Participant Demographics
Isolates included 60 from human clinical cases, 30 from foods, 30 from animal clinical cases, and 75 from environmental sources.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% credibility interval for recombination rates
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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