Impact of Schizophrenia on Quality of Life
Author Information
Author(s): Briggs Andrew, Wild Diane, Lees Michael, Reaney Matthew, Dursun Serdar, Parry David, Mukherjee Jayanti
Primary Institution: Oxford Outcomes Ltd, Oxford, UK
Hypothesis
To examine the impact of schizophrenia, its treatment, and treatment-related adverse events on quality of life from the perspective of schizophrenia patients and laypersons.
Conclusion
Events associated with schizophrenia and its treatment can significantly reduce patient quality of life, with relapse having the largest negative impact.
Supporting Evidence
- Stable schizophrenia had the highest mean utility scores.
- Relapse and EPS were associated with the lowest mean utility scores.
- Patients reported higher utilities than laypersons for stable schizophrenia and treatment-related adverse events.
Takeaway
This study shows that having schizophrenia and the side effects from its treatment can make life much harder, especially when patients have a relapse.
Methodology
The study used a time trade-off instrument to elicit quality of life utilities from 49 stable schizophrenia patients and 75 laypersons.
Potential Biases
Potential bias in utility values due to differences in perspectives between patients and laypersons.
Limitations
The study relied on a convenience sample of laypersons and may not fully represent the general population.
Participant Demographics
Patients were primarily diagnosed with paranoid schizophrenia and were mostly single with lower educational attainment compared to laypersons.
Statistical Information
P-Value
p = 0.022 for relapse
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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