Recurrences and Treatments After Surgery for Kidney Cancer
Author Information
Author(s): Petersson Rasmus Due MD, Niebuhr Malene H. MD, Jensen Christian Fuglesang S. MD, PhD, Azawi Nessn H. MD, PhD, Thomsen Frederik F. MD, PhD
Primary Institution: Copenhagen University Hospital, Herlev and Gentofte Hospital
Hypothesis
What are the patterns of recurrences and subsequent treatments in patients with recurrent renal cell carcinoma (RCC) after curative-intent surgery?
Conclusion
Treatments aimed at achieving no evidence of disease (NED) provide good oncological control in recurrent RCC without compromising overall survival compared to systemic treatments.
Supporting Evidence
- 91 patients experienced a first recurrence, with 49 receiving NED-aimed treatment.
- The 3-year overall survival for patients receiving NED-aimed treatment for their first recurrence was 83.1%.
- 30% of patients experienced a second recurrence in the same location as the first.
Takeaway
This study looked at patients who had kidney cancer surgery and found that many could have more surgery to remove cancer that came back, which helps them live longer.
Methodology
This is a retrospective study analyzing 525 patients who underwent surgery for RCC from 2010 to 2015, with follow-up data collected through patient chart reviews.
Potential Biases
Selection bias may affect the survival data due to the non-randomized nature of treatment selection.
Limitations
The study's retrospective design and lack of a standardized treatment protocol may introduce selection bias affecting survival data.
Participant Demographics
The median age of participants was 66 years, with 70% male and 30% female.
Statistical Information
P-Value
0.004
Confidence Interval
95% CI 72.3–93.8%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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