Drug Resistance in Tuberculosis in China
Author Information
Author(s): He Guang Xue, Zhao Yan Lin, Jiang Guang Lu, Liu Yu Hong, Xia Hui, Wang Sheng Fen, Wang Li Xia, Borgdorff Martien W, van der Werf Marieke J, van den Hof Susan
Primary Institution: National Center for TB control and prevention, China Center for Disease Control and Prevention (CDC), Beijing, PR China
Hypothesis
What is the prevalence of tuberculosis drug resistance in different provinces of China?
Conclusion
MDR-TB levels varied greatly between provinces in China, but on average were high compared to the global estimated average.
Supporting Evidence
- The weighted mean prevalence of MDR-TB among all cases was 9.3%.
- 5.4% of new cases were found to have MDR-TB.
- 25.6% of previously treated cases had MDR-TB.
- The study included data from 14,059 patients.
Takeaway
This study looked at how many people in China have drug-resistant tuberculosis, and found that many provinces have a lot of it.
Methodology
Surveys were conducted in ten provinces, testing drug resistance in newly diagnosed, smear-positive TB patients using drug susceptibility testing.
Potential Biases
Misclassification of previously treated cases as new cases may have occurred.
Limitations
The study may not represent all provinces in China, and some provinces had incomplete results reported.
Participant Demographics
The study included newly diagnosed, smear-positive TB patients from ten provinces in China.
Statistical Information
Confidence Interval
95% CI 455,093–614,215
Digital Object Identifier (DOI)
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