Cadherin–catenin expression in colorectal cancer and survival
Author Information
Author(s): Hugh T J, Dillon S A, Taylor B A, Pignatelli M, Poston G J, Kinsella A R
Primary Institution: Cellular Oncology Group, Department of Surgery, University of Liverpool
Hypothesis
The study investigates the role of cadherin–catenin complex expression in colorectal cancer and its correlation with patient survival.
Conclusion
Loss of certain cadherin–catenin components is associated with poor survival outcomes in colorectal cancer patients.
Supporting Evidence
- Loss of membranous expression of E-cadherin, α-catenin, and β-catenin was found in 52%, 85%, and 40% of tumors respectively.
- Widespread nuclear expression of β-catenin was seen in 18% of tumors.
- Loss of membranous α-catenin expression significantly correlated with tumor de-differentiation.
Takeaway
This study looked at how certain proteins in colorectal cancer cells can affect how long patients live after treatment. If these proteins are missing, it might mean the cancer is more aggressive.
Methodology
Immunohistochemical analysis of cadherin–catenin complex expression in colorectal cancers from 60 patients.
Statistical Information
P-Value
P = 0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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