Effects of Radiation Therapy on Tumor Biomarkers in Rectal Cancer
Author Information
Author(s): Gaber Alexander, Stene Christina, Hotakainen Kristina, Nodin Björn, Palmquist Ingrid, Bjartell Anders, Stenman Ulf-Håkan, Jeppsson Bengt, Johnson Louis B, Jirström Karin
Primary Institution: Lund University, Skåne University Hospital
Hypothesis
Does neoadjuvant radiotherapy affect concentrations of tumor-associated trypsin inhibitor in rectal cancer patients?
Conclusion
Radiation therapy does not affect TATI concentrations in tissue or serum in rectal cancer patients, and both TATI forms are associated with poor prognosis.
Supporting Evidence
- TATI concentrations in serum were significantly higher post-surgery in patients receiving short-term RT.
- High t-TATI expression was associated with a significantly shorter overall survival.
- S-TATI concentrations correlated with higher age and increased s-creatinine concentrations.
Takeaway
This study looked at how radiation therapy affects a specific protein related to cancer in rectal cancer patients, and found that the treatment doesn't change the protein levels.
Methodology
TATI was analyzed in serum and tissue samples from rectal cancer patients receiving different radiation treatments.
Potential Biases
Potential selection bias due to exclusion criteria and the specific demographics of the patient cohort.
Limitations
The study had a relatively small sample size and was limited to a specific patient population.
Participant Demographics
53 patients, 36 males (67.9%) and 17 females (32.1%), aged 75 and older were included.
Statistical Information
P-Value
P < 0.001 for short-term RT effects on s-TATI concentrations.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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