Outcome of Children with Resistant and Relapsed Hodgkin's Disease
Author Information
Author(s): N.D. James, J.E. Kingston, P.N. Plowman, S. Meller, R. Pinkerton, A. Barrett, R. Sandland, T.J. McElwain, J.S. Malpas
Primary Institution: St Bartholomew's Hospital and Royal Marsden Hospital
Hypothesis
What factors predict the response to salvage treatment in children with relapsed or resistant Hodgkin's disease?
Conclusion
Current therapeutic approaches are effective for many children with Hodgkin's disease, but certain subgroups have poor outcomes.
Supporting Evidence
- The overall actuarial survival for the whole patient group at 10 years was 81%.
- Patients relapsing within a year of diagnosis had a poor response to salvage therapy.
- Over half of the patients requiring salvage treatment had declared themselves within 2 years.
Takeaway
This study looked at children with Hodgkin's disease who didn't get better after treatment and found that some do survive despite many relapses.
Methodology
The study analyzed 169 children treated for Hodgkin's disease from 1974 to 1989, focusing on those who relapsed or did not achieve complete remission.
Limitations
The study had small sample sizes in some subgroups, which may limit the generalizability of the findings.
Participant Demographics
169 children under 16 years old, with 25 males and 10 females in the relapsed/resistant group.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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