Gut Microbiota and Hypertension in Kazakh Individuals
Author Information
Author(s): Abildinova Gulshara, Vochshenkova Tamara, Aitkaliyev Alisher, Abildinova Aizhan, Benberin Valeriy, Borovikova Anna, Bekenova Nazira, Kassiyeva Balzhan
Primary Institution: Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan
Hypothesis
The study aimed to investigate the potential role of the gut microbiota in arterial hypertension among individuals of the Kazakh population without insulin resistance.
Conclusion
The study found a significant association between the abundance of the phylum Firmicutes in the gut microbiota and the risk of arterial hypertension in Kazakh individuals without insulin resistance.
Supporting Evidence
- The abundance of Firmicutes was significantly associated with arterial hypertension.
- Logistic regression analysis indicated that Firmicutes influenced hypertension risk after adjusting for other factors.
- Correlation analysis revealed a negative association between Firmicutes and triglyceride levels.
Takeaway
This study suggests that the bacteria in our gut, especially a type called Firmicutes, might be linked to high blood pressure in people who don't have insulin resistance.
Methodology
The study used 16S rRNA gene sequencing of faecal samples from 197 Kazakh subjects and performed logistic regression analysis to assess the association between Firmicutes and hypertension.
Potential Biases
Potential unmeasured confounding factors may have influenced the results.
Limitations
The study had a small sample size, used faecal material which may not fully reflect the entire microbiome, and was cross-sectional, limiting causal inferences.
Participant Demographics
Participants were Kazakh individuals aged 38-58 years, with 73 women and 124 men.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.005–1.125
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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