Expression and function of angiopoietin-1 in breast cancer
2000
Role of Angiopoietin-1 in Breast Cancer
Sample size: 21
publication
Evidence: moderate
Author Information
Author(s): Hayes A J, Huang W-Q, Yu J, Maisonpierre P C, Liu A, Kern F G, Lippman M E, McLeskey S W, Li L-Y
Primary Institution: Georgetown University Medical Center
Hypothesis
What is the role of Angiopoietin-1 in tumor neovascularization in breast cancer?
Conclusion
Overexpression of Angiopoietin-1 did not enhance tumor growth and instead caused a significant retardation of tumor growth.
Supporting Evidence
- Angiopoietin-1 was expressed in only three of 21 breast cancer clinical specimens.
- High concentrations of Ang1 were produced in the conditioned media of transfected MCF-7 cells.
- Overexpression of Ang1 caused up to a 3-fold retardation of tumor growth.
Takeaway
The study looked at a protein called Angiopoietin-1 in breast cancer and found that making more of it didn't help the tumors grow faster; in fact, it made them grow slower.
Methodology
The expression of Ang1 was analyzed using laser-capture microdissection and RT-PCR on RNA from clinical breast cancer specimens.
Statistical Information
P-Value
0.003
Statistical Significance
p=0.003
Digital Object Identifier (DOI)
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