Resistance of Gram-negative Bacteria in Critically Ill Patients
Author Information
Author(s): Kotwinski D, Batra R, Olga T, Edgeworth J, Wyncoll D, Shankar-Hari M
Primary Institution: King's College London & Guy's and St Thomas' NHS Foundation Trust
Hypothesis
What are the antibiotic resistance rates in Gram-negative bacilli isolates at admission in critically ill adult patients?
Conclusion
Screening for Gram-negative bacilli resistance helps in choosing the right antibiotic treatment.
Supporting Evidence
- Of the 8,095 ICU admissions, 4,753 patients satisfied the inclusion criteria.
- The number of patients with gentamicin-resistant GNBs on admission has remained stable.
- Hospital-associated gentamicin resistance in GNB has fallen from 14.8% in 2002 to 8.3% in 2009.
- Patients with a positive admission screen are more likely to have the same resistant genus isolated from a nosocomial infection.
Takeaway
Doctors check for germs that resist medicine when patients come to the hospital, which helps them pick the right medicine to fight infections.
Methodology
An 8-year retrospective observational cohort study using prospectively collected data from a 30-bed referral ICU.
Limitations
The study only included the first admission from each patient over the 8-year period.
Participant Demographics
Adult patients admitted to the ICU at St Thomas' Hospital.
Digital Object Identifier (DOI)
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