The Role of IL-17A in Sjögren's Syndrome-like Disease in Mice
Author Information
Author(s): Nguyen Cuong Q, Yin Hongen, Lee Byung Ha, Carcamo Wendy C, Chiorini John A, Peck Ammon B
Primary Institution: University of Florida College of Dentistry
Hypothesis
Can IL-17A influence the development and onset of Sjögren's syndrome-like disease?
Conclusion
IL-17A is a significant inflammatory cytokine that can induce Sjögren's syndrome-like pathology in non-susceptible mice.
Supporting Evidence
- Mice treated with IL-17A developed symptoms similar to Sjögren's syndrome.
- Increased levels of IL-17A and IL-6 were found in the serum of treated mice.
- Lymphocytic foci were observed in the salivary glands of IL-17A treated mice.
Takeaway
This study shows that a protein called IL-17A can make mice sick in a way similar to a disease that causes dry mouth and dry eyes.
Methodology
C57BL/6J mice were treated with adenovirus vectors expressing IL-17A or LacZ, and their salivary glands were analyzed for disease symptoms.
Potential Biases
Potential bias in the selection of mouse age and treatment timing.
Limitations
The study was conducted in a mouse model, which may not fully replicate human disease.
Participant Demographics
C57BL/6J mice, aged 6 to 17 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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