H3K4me3 and Transposable Elements in Early Embryo Development
Author Information
Author(s): Chen Xiaowei, Yang Hua, Wang Liqin, Chen Ying, Yang Yingnan, Chen Haonan, Wang Feng, Zhang Yanli, Deng Mingtian
Primary Institution: Nanjing Agricultural University
Hypothesis
The study investigates the genome-wide distribution of H3K4me3 and its role in regulating transposable elements during early embryo development.
Conclusion
H3K4me3 plays important roles in regulating transposable element expression and is crucial for zygotic genome activation and cell fate determination.
Supporting Evidence
- H3K4me3 distribution is dynamically changed and correlated with early embryo development in sheep.
- Broad H3K4me3 domains were removed during early embryo development.
- Promoter H3K4me3 enrichment was increased and correlated with gene upregulation during zygotic genome activation.
- H3K4me3 enrichment in transposable elements was greatly increased during zygotic genome activation following Kdm5b knockdown.
Takeaway
This study looks at how a special marker in DNA helps control genes during the early stages of embryo development in sheep and mice.
Methodology
The study used CUT&Tag to analyze H3K4me3 distribution during early embryo development and embryonic stem cells.
Digital Object Identifier (DOI)
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