Thermochemotherapy-induced resistance to cyclophosphamide
1988
Thermochemotherapy-Induced Resistance to Cyclophosphamide
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): M. Urano, J. Kahn, L.A. Kenton
Primary Institution: Massachusetts General Hospital, Harvard Medical School
Hypothesis
Does hyperthermia induce resistance to cyclophosphamide in tumor treatment?
Conclusion
The study suggests that drug-induced resistance is a key mechanism in thermochemotherapy resistance.
Supporting Evidence
- Hyperthermia enhances the cytotoxic effect of some chemotherapeutic agents.
- Drug resistance developed following the first administration of cyclophosphamide.
- Combined treatments of cyclophosphamide and hyperthermia showed a flat dose response curve.
Takeaway
When mice with tumors were treated with heat and a drug called cyclophosphamide, they became less responsive to the drug over time.
Methodology
Mice with tumors were treated with cyclophosphamide and hyperthermia, and tumor growth time was measured.
Limitations
The study primarily used a single type of tumor in mice, which may limit the generalizability of the findings.
Participant Demographics
C3Hf/Sed mice, 10 to 12 weeks old.
Statistical Information
Confidence Interval
95% confidence limit
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