Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients
1999
Cathepsin-D and Breast Cancer Prognosis
Sample size: 2810
publication
Evidence: high
Author Information
Author(s): Foekens J A, Look M P, Vries J Bolt-de, Gelder M E Meijer-van, Putten W L J van, Klijn J G M
Primary Institution: Rotterdam Cancer Institute (Daniel den Hoed Kliniek)
Hypothesis
Is cathepsin-D expression in primary breast cancer associated with patient prognosis?
Conclusion
High levels of cathepsin-D in breast cancer tumors are linked to worse survival outcomes.
Supporting Evidence
- High cathepsin-D levels are associated with poor relapse-free and overall survival.
- The median follow-up for patients still alive was 88 months.
- Multivariate analysis confirmed the association of high cathepsin-D with poor prognosis.
- Adjuvant therapy improved prognosis in node-positive patients.
Takeaway
If a breast cancer tumor has a lot of cathepsin-D, it might mean the patient will have a harder time recovering.
Methodology
Analyzed cytosolic extracts from 2810 breast tumors for cathepsin-D levels and correlated with patient prognosis.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website