How Diet and Development Affect Ascaroside Expression in C. elegans
Author Information
Author(s): Fatma Kaplan, Jagan Srinivasan, Parag Mahanti, Ramadan Ajredini, Omer Durak, Rathika Nimalendran, Paul W. Sternberg, Peter E. A. Teal, Frank C. Schroeder, Arthur S. Edison, Hans T. Alborn
Primary Institution: Center for Medical, Agricultural and Veterinary Entomology, USDA-ARS
Hypothesis
Ascaroside expression in C. elegans is influenced by diet and developmental stage.
Conclusion
Ascaroside expression varies significantly with the developmental stage and environmental conditions of C. elegans.
Supporting Evidence
- Ascaroside production is highest just before mating.
- Ascaroside levels are significantly lower in dauer larvae.
- Dietary conditions greatly influence ascaroside release.
Takeaway
C. elegans changes the way it produces certain chemicals based on what it eats and how old it is.
Methodology
The study involved culturing C. elegans on controlled diets and quantifying ascarosides using LC-MS.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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