Stability from Structure: Metabolic Networks Are Unlike Other Biological Networks
2009
Metabolic Networks Are Different from Other Biological Networks
publication
Evidence: moderate
Author Information
Author(s): P. van Nes, D. Bellomo, MJT Reinders, D. de Ridder
Primary Institution: Delft University of Technology
Hypothesis
Are structurally stable motifs enriched in metabolic networks?
Conclusion
Structurally stable network motifs are not enriched in metabolic networks.
Supporting Evidence
- The choice of null model significantly influences motif enrichment results.
- The BRENDA distribution provides a more biologically relevant assessment of stability.
- Removing currency metabolites alters the topology of the metabolic network.
Takeaway
This study looked at how the structure of metabolic networks affects their stability. It found that the stable patterns seen in other biological networks don't apply to metabolic networks.
Methodology
The study extended a method for analyzing network motifs by changing the null model and incorporating enzymatic regulation.
Limitations
The study's conclusions may not apply to all types of biological networks, and the analysis is limited to local stability.
Digital Object Identifier (DOI)
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