Is there a role for retinoids to treat minimal residual disease in neuroblastoma?
2000
Role of Retinoids in Treating Neuroblastoma
Editorial
Author Information
Author(s): Matthay K K, Reynolds C P
Primary Institution: Department of Pediatrics, University of California San Francisco School of Medicine
Hypothesis
Can retinoids effectively treat minimal residual disease in neuroblastoma?
Conclusion
High-dose levels of retinoids are optimal for treating minimal residual disease in neuroblastoma.
Supporting Evidence
- High drug levels of retinoids are required for optimal efficacy against neuroblastoma.
- Low-dose 13-cis-RA does not have clinical efficacy against neuroblastoma in minimal residual disease.
- High-dose levels of retinoids are optimal for treating minimal residual disease in neuroblastoma.
Takeaway
Doctors are looking at how high doses of a medicine called retinoids might help kids with a type of cancer called neuroblastoma, especially when there's still some cancer left after treatment.
Digital Object Identifier (DOI)
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