Right Ventricular Volumes and Function in Thalassemia Major Patients
Author Information
Author(s): Meloni Antonella, Dell'Amico Maria Chiara, Favilli Brunella, Aquaro Giovanni D, Lamia Ait-Ali, Chiodi Elisabetta, Ascioti Claudio, Renne Stefania, Bitti Pier Paolo, Gerardi Calogera, Positano Vincenzo, Lombardi Massimo, Pepe Alessia
Primary Institution: “G. Monasterio” Foundation and Institute of Clinical Physiology, CNR, Pisa, Italy
Hypothesis
What are the normal ranges for right ventricular volumes and ejection fraction in well-treated Thalassemia Major patients without myocardial iron overload?
Conclusion
Males with Thalassemia Major showed significantly higher right ventricular ejection fraction compared to healthy controls.
Supporting Evidence
- TM patients showed significantly lower body surface area than the controls.
- TM males showed significantly higher RV ejection fraction compared to controls.
- All left ventricular volume indexes were significantly larger in males than in females.
Takeaway
This study looked at heart function in boys and girls with a blood disorder called Thalassemia Major and found that boys had better heart function than healthy kids.
Methodology
The study evaluated right ventricular function using cardiovascular magnetic resonance in Thalassemia Major patients and healthy controls.
Limitations
The study only included patients without known cardiac disease and may not represent all Thalassemia Major patients.
Participant Demographics
142 Thalassemia Major patients and 71 healthy subjects matched for age and sex.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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