Deletions of the region 17p11-13 in advanced melanoma revealed by cytogenetic analysis and fluorescence in situ hybridization
1999
Deletions in Melanoma and the Role of p53
Sample size: 11
publication
Evidence: moderate
Author Information
Author(s): Okamoto I, Pirc-Danoewinata H, Ackermann J, Drach J, Wadl H Schlagbauer, Jansen B, Wolff K, Pehamberger H, Marosi C
Primary Institution: University of Vienna
Hypothesis
What is the role of the p53 gene in human malignant melanoma?
Conclusion
The study found that deletions in the 17p11-13 region are common in malignant melanomas, suggesting a link to the cancer's aggressiveness.
Supporting Evidence
- Six melanomas showed deletions of the short arm of chromosome 17.
- Three malignant melanomas had clones with only one p53-allele.
- Four malignant melanomas showed a reduced number of signals at the p53 locus.
Takeaway
Researchers looked at skin cancer samples and found that a specific part of a gene is often missing, which might make the cancer worse.
Methodology
Cytogenetic analysis and fluorescence in situ hybridization (FISH) were used on melanoma metastases from patients.
Participant Demographics
Patients with advanced melanoma.
Digital Object Identifier (DOI)
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