Comorbidity between epilepsy and headache/migraine: the other side of the same coin!
2011
Comorbidity between Epilepsy and Headache/Migraine
Commentary
Author Information
Author(s): Striano Pasquale, Belcastro Vincenzo, Verrotti Alberto, Parisi Pasquale
Conclusion
The study suggests that the SCN1A gene is not involved in the pathogenesis of comorbidity between headache/migraine and epilepsy.
Supporting Evidence
- Both epilepsy and headache/migraine are chronic disorders with episodic attacks.
- Recent data suggest shared genetic substrates and phenotypic-genotypic correlations.
- Neuronal hyperexcitability and increased susceptibility to cortical spreading depression are important mechanisms in this association.
- International efforts are needed to collect large well-phenotyped samples to understand the genetic mechanisms.
Takeaway
This article talks about how epilepsy and headaches can happen together, but a specific gene doesn't seem to cause this problem.
Digital Object Identifier (DOI)
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