Genetic Variants and Oral Cancer
Author Information
Author(s): Yang Wei-En, Lin Chiao-Wen, Chen Yi-Tzu, Su Chun-Wen, Yeh Chia-Ming, Lee Chia-Yi, Yang Shun-Fa, Chen Mu-Kuan
Primary Institution: Chung Shan Medical University
Hypothesis
This study investigates the association between RORB single-nucleotide polymorphisms and clinical manifestations of oral squamous cell carcinoma (OSCC).
Conclusion
RORB single-nucleotide polymorphisms rs3750420 and rs10781247 are associated with adverse clinical characteristics in OSCC.
Supporting Evidence
- RORB SNP rs10781247 variants were significantly associated with moderate to poor cellular differentiation in patients with OSCC.
- Among betel quid chewers with OSCC, rs10781247 variants were significantly associated with moderate to poor cell differentiation.
- RORB SNP rs3750420 variants were significantly associated with larger tumor size in individuals with buccal mucosa cancer.
- RORB mRNA levels were significantly higher in patients with head and neck squamous cell carcinoma compared with controls.
- RORB mRNA levels were significantly higher in stage IV tumors than in stage III tumors.
Takeaway
This study found that certain genetic changes are linked to worse outcomes in patients with oral cancer, especially for those who chew betel quid.
Methodology
The study included 1174 male patients without OSCC and 1254 male patients with OSCC, genotyping three RORB SNPs using TaqMan assays.
Potential Biases
The population in the Cancer Genome Atlas database differs from the study cohort, which may introduce bias.
Limitations
The study used a case-control design, lacked detailed data on risk factors, and had a homogeneous population limiting generalizability.
Participant Demographics
The study focused on male patients, primarily Han Taiwanese.
Statistical Information
P-Value
0.042
Confidence Interval
1.011 to 1.947
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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