Informative Rat Genetic Markers and Strains
Author Information
Author(s): Mashimo Tomoji, Voigt Birger, Tsurumi Toshiko, Naoi Kuniko, Nakanishi Satoshi, Yamasaki Ken-ichi, Kuramoto Takashi, Serikawa Tadao
Primary Institution: Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University
Hypothesis
Can a set of highly polymorphic SSLP markers improve the genetic evaluation of rat strains?
Conclusion
The study provides a valuable set of SSLP markers and genetically defined rat strains that can aid in QTL analysis and the development of new genetic resources.
Supporting Evidence
- 357 SSLP markers were selected for their distribution patterns across the rat genome.
- The average number of informative markers between all possible pairs of strains was 259.
- The study constructed a rat family tree to clarify the genetic background of the strains.
Takeaway
Scientists found a lot of useful markers in rats that help them understand how different rat strains are related and how they can be used in research.
Methodology
The study involved genotyping 122 rat strains using 357 SSLP markers to evaluate their genetic diversity.
Participant Demographics
The study included 122 rat strains, comprising 65 inbred strains, 22 substrains, 29 recombinant inbred strains, and 6 wild rats.
Digital Object Identifier (DOI)
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