SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum
2008
Understanding How RNA Viruses Replicate
publication
Evidence: moderate
Author Information
Author(s): Mark R. Denison
Primary Institution: Vanderbilt University Medical Center
Hypothesis
How much do we really understand about how +RNA viruses usurp and transform the intracellular architecture of host cells when they replicate?
Conclusion
The study reveals that SARS-CoV replication is supported by a complex network of modified endoplasmic reticulum membranes.
Supporting Evidence
- The study suggests common mechanisms between coronaviruses and other +RNA viruses.
- It presents a model for testing questions raised by previous studies.
- The results indicate that the majority of SARS-CoV double-stranded RNA resides within the interior of double-membrane vesicles.
Takeaway
This study shows how certain viruses change the inside of cells to help them make more copies of themselves.
Methodology
The study used light and electron microscopy to visualize the replication structures of SARS-CoV in infected cells.
Digital Object Identifier (DOI)
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