Oral Microbiome in Older Adults with Dementia
Author Information
Author(s): Jeong Sol-ah, Jung Bock-Young, Lee Insuk, Cha Jun Hyung, Choi Yejun
Primary Institution: Yonsei University, Seoul, Republic of Korea
Hypothesis
The study aimed to identify the diversity and composition of the oral microbiome in older adults with dementia and compare it to healthy individuals.
Conclusion
The oral microbiome may serve as a potential biomarker for the diagnosis and prevention of dementia.
Supporting Evidence
- Fusobacteriota was more abundant in both the tongue and saliva of the dementia group compared to the healthy group.
- Pseudomonadota is more dominant in the healthy group.
- Fusobacterium periodonticum was found to be more abundant as the K-MMSE scores decreased.
- Prevotella jejuni, Streptococcus anginosus, and Streptococcus gordonii are more enriched in the Dementia group compared to the healthy group.
Takeaway
Researchers looked at the mouth bacteria of older people with dementia and found differences compared to healthy older people, which might help in diagnosing dementia.
Methodology
Next-generation sequencing was used to analyze saliva samples from participants, and statistical analysis was performed using MaAsLin2.
Participant Demographics
58 older adults aged 65 years and older, including 30 with dementia and 28 healthy individuals.
Digital Object Identifier (DOI)
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