Using FET PET for Radiotherapy Planning in High-Grade Glioma
Author Information
Author(s): Weber Damien C, Zilli Thomas, Buchegger Franz, Casanova Nathalie, Haller Guy, Rouzaud Michel, Nouet Philippe, Dipasquale Giovanna, Ratib Osman, Zaidi Habib, Vees Hansjorg, Miralbell Raymond
Primary Institution: Geneva University Hospital
Hypothesis
Can FET PET imaging improve the delineation of tumor volumes for radiotherapy planning in high-grade glioma patients?
Conclusion
FET PET imaging provides excellent interrater reliability for tumor volume delineation, but significant differences exist between biological and morphological tumor volumes.
Supporting Evidence
- Interrater agreement for BTV delineation was excellent (ICC = 0.9).
- BTVs were not significantly different from GTVs (p = 0.9).
- CTV was significantly larger than both BTVs and GTVs (p < 0.01).
- FET uptake extended beyond gadolinium enhancement in a majority of patients.
Takeaway
Doctors used a special scan to see how big the tumors were in patients with brain cancer, and they found that the way they measured the tumors could be very different depending on the method used.
Methodology
Nineteen patients with high-grade glioma were assessed using FET PET-CT for radiotherapy planning, comparing biological and morphological tumor volumes.
Potential Biases
Potential bias in observer delineation of tumor volumes.
Limitations
The study was limited to a small sample size and specific patient demographics.
Participant Demographics
19 patients (10 females, 9 males) aged 20.9 to 75 years with high-grade glioma.
Statistical Information
P-Value
0.9
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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