Mezlocillin Levels in Blood and Tissue
Author Information
Author(s): Sandra Mya, Ron E. Gain, Bryan Larsen
Primary Institution: Marshall University School of Medicine
Hypothesis
This study evaluated the blood and uterine tissue concentration of mezlocillin, a broad-spectrum penicillin.
Conclusion
The serum concentration of mezlocillin after IV infusion of 4 g was greater than that required to inhibit the majority of the most significant organisms responsible for post-hysterectomy sepsis.
Supporting Evidence
- The average serum concentration of mezlocillin was 207.5 µg/ml.
- The average tissue level was 117.2 µg/ml.
- Serum samples contained from 81.2 to 358 µg of mezlocillin/ml.
- The correlation coefficient for the standard curve was 0.9997.
Takeaway
The study looked at how much mezlocillin, an antibiotic, is found in the blood and tissue after giving it to women before surgery. It found that there is enough of the medicine in the blood to help fight infections.
Methodology
A liquid chromatographic method was adapted to measure mezlocillin in serum and tissue from patients treated with the drug.
Limitations
The study was not designed to be a pharmacokinetic study, and the time after infusion that the tissue sample was removed and the serum sample was taken varied.
Participant Demographics
14 premenopausal women scheduled to undergo vaginal hysterectomy.
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