Smart Hydrogels for Drug Delivery
Author Information
Author(s): Bucatariu Sanda, Cosman Bogdan, Constantin Marieta, Ailiesei Gabriela Liliana, Rusu Daniela, Fundueanu Gheorghe
Primary Institution: “Petru Poni” Institute of Macromolecular Chemistry
Hypothesis
Can we create a hydrogel that responds to pH and temperature changes to deliver drugs effectively?
Conclusion
The developed hydrogels can regain thermosensitivity and modulate drug release in response to specific biomolecules.
Supporting Evidence
- The hydrogels were able to recover thermosensitivity when interacting with specific biomolecules.
- High drug loading efficiency was achieved, exceeding 95% for all samples.
- The swelling behavior of the hydrogels was significantly affected by the presence of triggering agents.
Takeaway
These smart gels can change their shape and release medicine when they sense changes in the body, like temperature or pH.
Methodology
The hydrogels were synthesized using a solvent-free thermal cross-linking method and characterized using various spectroscopic techniques.
Limitations
The hydrogels may lose thermosensitivity under physiological conditions without the presence of triggering agents.
Digital Object Identifier (DOI)
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