Platinum(II)-Acyclovir Complexes: Synthesis and Activity
Author Information
Author(s): M. Coluccia, A. Boccarelli, C. Cermelli, M. Portolani, G. Natile
Primary Institution: Dipartimento di Scienze Biomediche e Oncologia Umana, Bari, Italy
Hypothesis
The platinum(II) complex with acyclovir will maintain antiviral activity and exhibit anticancer properties.
Conclusion
The platinum-acyclovir complex shows antiviral and anticancer activities, being less potent than the parent drugs on a mole-equivalent basis but equally effective as cisplatin at equitoxic dosages.
Supporting Evidence
- The platinum-acyclovir complex maintained antiviral activity with an ID50 of 7.85 µM compared to 1.02 µM for acyclovir.
- In vivo, the platinum-acyclovir complex showed a %T/C of 209, similar to cisplatin's 211.
- The complex was effective against a cisplatin-resistant subline of P388 leukaemia with a %T/C of 140.
Takeaway
Scientists made a new medicine by combining platinum with acyclovir, which helps fight viruses and cancer. It works well but isn't as strong as the original medicines when compared equally.
Methodology
The study involved synthesizing the platinum-acyclovir complex and testing its antiviral and anticancer properties in vitro and in vivo using P388 leukaemia-bearing mice.
Limitations
The platinum-acyclovir complex showed lower solubility and efficacy on a molar basis compared to acyclovir and cisplatin.
Participant Demographics
Mice were used for in vivo testing, specifically B6D2F1 mice.
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