Genetic Changes in Bladder Cancer
Author Information
Author(s): Watters A D, Latif Z, Forsyth A, Dunn I, Underwood M A, Grigor K M, Bartlett J M S
Primary Institution: University Department of Surgery, Glasgow Royal Infirmary
Hypothesis
Alteration of key cell cycle modulators c-myc and CCND1 via gene alterations drives progression of superficial and locally invasive TCC.
Conclusion
Amplification of CCND1 or alterations in c-myc/CCND1 early in bladder cancer may have clinical relevance in promoting and predicting progression to detrusor-muscle-invasive transitional cell carcinoma.
Supporting Evidence
- Two out of 16 patients with ⩾pT2 had CCND1 amplification.
- Six out of 31 patients had amplification of CCND1 in their detrusor muscle invasive tumours.
- Two out of 31 patients had amplification of c-myc.
Takeaway
This study found that changes in certain genes can help predict how bladder cancer will progress, which could help doctors treat it better.
Methodology
Fluorescence in situ hybridisation (FISH) was used to analyze gene and chromosome copy numbers in tumor samples.
Limitations
The study had a small sample size and focused only on specific genetic alterations.
Participant Demographics
Average age of participants was around 70 years, with a male to female ratio of approximately 13:3.
Statistical Information
P-Value
0.001
Statistical Significance
p=0.001
Digital Object Identifier (DOI)
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