How Toxins and Viruses Use Retrograde Transport to Enter Cells
Author Information
Author(s): Robert A Spooner, Daniel C Smith, Andrew J Easton, Lynne M Roberts, J Michael Lord
Primary Institution: Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
Hypothesis
Do toxins and viruses that depend upon retrograde trafficking follow common routes?
Conclusion
There is no common pathway utilized for retrograde transport by all of these pathogens, with the choice of route determined by the particular receptor utilized.
Supporting Evidence
- Emerging data suggests that there is no common pathway utilized for retrograde transport by all of these pathogens.
- The choice of route for retrograde transport is determined by the particular receptor utilized.
- CTx and ricin transport is depicted as STx-like from early endosomes to the TGN, although there may be multiple routes.
Takeaway
This study looks at how certain toxins and viruses get into cells by traveling backwards through the cell's transport system, and it finds that they don't all use the same path.
Methodology
The study reviews existing research on the retrograde transport mechanisms of various toxins and viruses.
Limitations
The details of the pathways taken by SV40 and Py to reach the ER are still under investigation.
Digital Object Identifier (DOI)
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