Human Papillomavirus Types in Invasive Cervical Cancer Worldwide
Author Information
Author(s): Clifford G M, Smith J S, Plummer M, Muñoz N, Franceschi S
Primary Institution: International Agency for Research on Cancer
Hypothesis
To identify the most prevalent HPV types associated with invasive cervical cancer worldwide and within five geographic regions.
Conclusion
The study found that HPV16 and HPV18 are the most common types associated with invasive cervical cancer globally.
Supporting Evidence
- HPV DNA was found in 99.7% of cervical cancer cases studied.
- HPV16 was the most common type found in squamous cell carcinoma.
- HPV18 was more prevalent in adenocarcinoma than in squamous cell carcinoma.
- Overall HPV prevalence varied little between geographical regions.
- HPV vaccines could significantly reduce the incidence of invasive cervical cancer.
Takeaway
This study looked at many cases of cervical cancer around the world and found that most of them were caused by certain types of a virus called HPV.
Methodology
The study selected relevant literature from Medline and ISI databases, focusing on studies with at least 20 cases of invasive cervical cancer and using PCR methods to identify HPV DNA.
Potential Biases
Variations in PCR methods and the potential for missed multiple infections may introduce bias in the prevalence estimates.
Limitations
The cases included are not representative of the worldwide distribution of invasive cervical cancer, with underrepresentation from Africa and Asia.
Participant Demographics
The study included cases from various regions including Africa, Asia, Europe, North America, and South and Central America.
Statistical Information
P-Value
p<0.001
Confidence Interval
(76.4–92.7)
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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