CYP1A1 Genetic Polymorphism and Breast Cancer Risk in Postmenopausal Women
Author Information
Author(s): Huang C-S, Shen C-Y, Chang K-J, Hsu S-M, Chern H-D
Primary Institution: National Taiwan University
Hypothesis
CYP1A1 genetic polymorphism may be a susceptibility factor for breast cancer.
Conclusion
CYP1A1 polymorphism is a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan.
Supporting Evidence
- The CYP1A1 Msp1 polymorphism was found to be a significant factor in determining the risk of breast cancer.
- The homozygous variant had an adjusted odds ratio of 1.98 compared to non-homozygous variants.
- The Msp1 polymorphism was especially significant in postmenopausal women.
Takeaway
This study found that a specific genetic change in the CYP1A1 gene can make postmenopausal women in Taiwan more likely to get breast cancer.
Methodology
Case control study comparing 150 breast cancer patients with 150 healthy controls.
Limitations
Further study with a large sample size should be considered to address issues of interactions between CYP1A1 and other risk factors.
Participant Demographics
Postmenopausal Chinese women in Taiwan.
Statistical Information
Confidence Interval
95% CI = 1.01–3.99
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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